2083 Lawrenceville Road, Lawrenceville, NJ 08648
1978 Ph.D., Cell and Molecular Biology, University of Southern California, Los Angeles, CA
1973 B.S., Biology, American University, Washington, D.C.,
Research Interests & University Activities
My laboratory has been studying proteases, protease inhibitors and cancer. Our focus most recently has been examining the effect of protease inhibitors, particularly alpha1-antitrypsin (alpha1-AT) on breast and brain tumor cells. We have observed suppression of growth factor release and growth in soft agarin both breast and brain tumor cell lines. This suggests alpha1-AT may be acting as atumor suppressor. Identification and characterization of the membrane proteasesuggests it is an elastase-like membrane protease.
I coordinate activites of our Rider University Science Advisory Board. Representatives from academic institutions and corporations such as, Bristol-Myers Squibb, Merck, FMC, Wyeth-Ayerst, Besselaar, Johnson and Johnson, Janssen, American Cyanamid, Princeton University and The Institute for Advanced Study provide our science programs with advise and opportunities for collaboration and cooperation.
National Institutes of Health
Fannie E. Rippel Foundation
New Jersey Commission on Cancer Research
Life Sciences:Cell and Genetic Emphasis (BIO-101)
Cell and Molecular Biology and Lab (BIO-117)
Advanced Cell & Molecular Biology and Lab (BCH-330)
Genetic Engineering and the Philosophy of Science
Finlay, T. H., Tamir, S., Kadner, S.S., Cruz, M.R., Yavelow, J., and Levitz, M. #1-Antitrypsin and Anchorage Independent Growth of MCF-7 Breast Cancer Cells. Endocrinology, 133: 996-1002, (1993).
Nickels, J.T. Jr. , Schepis, L.T. and Yavelow, J., Isolation and characterization of chymotrypsin-like enzymes from transformed fibroblasts. J. Foods Chemistry, 18:1-15, 1994.
Yavelow, J., Tuccillo, A.M., Kadner, S.S., Katz, J. and Finlay, T.H.##1-Antitrypsin blocks TGF# release from MCF-7 Human Breast Cancer Cells. J. Clin. Endocrinology and Metabolism, 82:745-752, 1997.
Fitzpatrick, E., McBride, S., Yavelow, J., Najmi, S., Zanzucchi, P., Wieder, R. Microfuidic techniques for Single-Cell Protein Expression Analysis. Clinical chemistry, 54:6 1080-1088, 2006.
Yavelow, J. Rider University Science Advisory Board: A mechanism for successful partnering between the University, Industry and the Community. Council on Undergraduate Research (CUR) 27:1, September 2006.