Jonathan Yavelow
- Email Address: yavelow@rider.edu
- Phone: (609) 896-5093
- Office: Science Hall 324A
- View My Office Hours
- Mailing Address: 2083 Lawrence Road, Lawrenceville, NJ 08648
| Education | |
| 1978 | Ph.D., Cell and Molecular Biology, University of Southern California, Los Angeles, CA |
| 1973 | B.S., Biology, American University, Washington, D.C., |
| Research Interests & University Activities | |
| My laboratory has been studying proteases, protease inhibitors and cancer. Our focus most recently has been examining the effect of protease inhibitors, particularly alpha1-antitrypsin (alpha1-AT) on breast and brain tumor cells. We have observed suppression of growth factor release and growth in soft agarin both breast and brain tumor cell lines. This suggests alpha1-AT may be acting as atumor suppressor. Identification and characterization of the membrane proteasesuggests it is an elastase-like membrane protease. I coordinate activites of our Rider University Science Advisory Board. Representatives from academic institutions and corporations such as, Bristol-Myers Squibb, Merck, FMC, Wyeth-Ayerst, Besselaar, Johnson and Johnson, Janssen, American Cyanamid, Princeton University and The Institute for Advanced Study provide our science programs with advise and opportunities for collaboration and cooperation. | |
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| Research Funding | |
| National Institutes of Health | |
| Fannie E. Rippel Foundation | |
| New Jersey Commission on Cancer Research | |
| Courses Taught | |
| Cell and Molecular Biology and Lab (BIO-117) | |
| Advanced Cell & Molecular Biology and Lab (BCH-330) | |
| Genetic Engineering and the Philosophy of Science | |
| Selected Publications | |
Finlay, T. H., Tamir, S., Kadner, S.S., Cruz, M.R., Yavelow, J., and Levitz, M. #1-Antitrypsin and Anchorage Independent Growth of MCF-7 Breast Cancer Cells. Endocrinology, 133: 996-1002, (1993).
Nickels, J.T. Jr. , Schepis, L.T. and Yavelow, J., Isolation and characterization of chymotrypsin-like enzymes from transformed fibroblasts. J. Foods Chemistry, 18:1-15, 1994.
Yavelow, J., Tuccillo, A.M., Kadner, S.S., Katz, J. and Finlay, T.H.##1-Antitrypsin blocks TGF# release from MCF-7 Human Breast Cancer Cells. J. Clin. Endocrinology and Metabolism, 82:745-752, 1997.
Fitzpatrick, E., McBride, S., Yavelow, J., Najmi, S., Zanzucchi, P., Wieder, R. Microfuidic techniques for Single-Cell Protein Expression Analysis. Clinical chemistry, 54:6 1080-1088, 2006.
Non-Technical Publication:
Yavelow, J. Rider University Science Advisory Board: A mechanism for successful partnering between the University, Industry and the Community. Council on Undergraduate Research (CUR) 27:1, September 2006.
